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| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Bad rabbit polyclonal antibody |
Gene Name: | Bcl2-associated agonist of cell death |
Synonyms: | BAD, BBC2, BBC6, BCL2L8, Bcl-XL/Bcl-2-Associated Death Promoter |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Bad |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion outer membrane, Cytoplasm |
Uniprot ID: | Q61337, Q92934, O35147 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 300-1: 600 | brain, lung, spleen |
Background
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Images
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Immunohistochemistry of paraffin embedded rat brain using BAD (GB11198) at dilution of 1:300 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using BAD (GB11198) at dilution of 1:300 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using BAD (GB11198) at dilution of 1:300 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using BAD (GB11198) at dilution of 1:300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
