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Anti-Bcl-XL Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Bcl-2-like protein 1 |
Synonyms: | BAD, BBC2, BBC6, BCL2L8, Bcl-XL/Bcl-2-Associated Death Promoter |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse bcl xl |
Uniprot ID: | Q64373 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion membrane, Nucleus, Cytoplasm, Cytoskeleton |
Predicted MW. / Observed MW. | 26 kDa / 32 kDa |
Product Usage Information
WB | Human | 1: 300-1: 400 | Hela, Jurkat |
Background
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase FF activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X promotes apoptosis.
Images
| Western blot analysis of Bcl-XL (GB115565) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
