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Anti-Beta Arrestin 2 Rabbit pAb (100 μl)
| Reactivity: | M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Beta-arrestin-2 |
Synonyms: | ARB2, ARR2, ARRB2, Arrestin beta 2, arrestin, beta 2, BARR2, Beta arrestin 2 |
Immunogen: | Recombinant protein corresponding to Mouse Beta Arrestin 2 |
Uniprot ID: | Q91YI4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 46 kDa / 50 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 800 | brain |
IHC/IF | Mouse | 1: 1000-1: 3000 | pancreas |
Background
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).
Images
| Western blot analysis of ARRB2 (GB114512) at dilution of 1: 800 |
| Immunofluorescence of paraffin embedded mouse pancreas using ARRB2 (GB114512) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
