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Anti-CARM1 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CARM1 rabbit polyclonal |
Gene Name: | Histone-arginine methyltransferase CARM1 |
Synonyms: | Prmt4, Protein arginine N-methyltransferase 4, PRMT 4, Coactivator-associated arginine methyltransferase 1, Carm1 |
Immunogen: | Recombinant protein corresponding to Mouse CARM1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 800-1: 2000 | brain |
IF | Mouse, Rat | 1: 400-1: 800 | brain |
Background
CARM1, also named as PRMT4, belongs to the protein arginine N-methyltransferase family. It is a dual functional coregulator that facilitates transcription initiation by methylation of Arg17 and Arg26 of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein. CARM1 functions as a coactivator for many nuclear receptors, such as oestrogen receptor, androgen receptor, thyroid receptor and farnesoid X-receptor. It also coactivates other transcription factors such as myocyte enhancer factor 2C (MEF2C), β-catenin, p53, nuclear factor (NF)-kB and the cAMP-responsive element-binding factor. The enzymatic activity and coactivator function of CARM1 has been found to be inactivated through phosphorylation at a conserved serine residue at mitosis stage.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse brain using CARM1 (GB111036) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using CARM1 (GB111036) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
