Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CBL rabbit polyclonal |
Gene Name: | E3 ubiquitin-protein ligase CBL |
Synonyms: | CBL, C-CBL2, FRA11B, NSLL, RNF55, Cbl proto-oncogene |
Immunogen: | Recombinant protein corresponding to Mouse CBL |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 101 kDa |
Observed MW. | 120 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | lymph gland, testis |
Background
Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia. CBL acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. It can recognize activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. CBL protein is also an adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface.
Images
 |
Western blot analysis of cb1 (GB11630) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
