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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Scavenger receptor cysteine-rich type 1 protein M130 |
Synonyms: | CD163, CD163 molecule, Hemoglobin scavenger receptor, M130, MM130, sCD163, SCARI1 |
Immunogen: | Recombinant protein corresponding to Mouse CD163 |
Uniprot ID: | Q2VLH6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 121 kDa / 130-160 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 1200-1: 1500 | spleen, lung, lymph nodes |
Background
CD163 is a transmembrane protein which belongs to the scavenger receptor cysteine-rich (SRCR) superfamily. This protein is a scavenger receptor for the hemoglobin-haptoglobin complex and is a marker for monocytes and macrophages. Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity.
Images
| WB analysis of CD163 (GB11340). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 1200, 4°C overnight. Secondary antibody:HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
