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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD40 rabbit polyclonal antibody |
Gene Name: | Tumor necrosis factor receptor superfamily member 5 |
Synonyms: | B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5, CDw40, GP39, HIGM1, IGM, IMD3, TBAM |
Immunogen: | Recombinant protein corresponding to Mouse CD40 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 45 kDa |
Uniprot ID: | P27512, Q4QQW2 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | spleen, thymus, lymph nodes |
Background
CD40, also named as TNFRSF5 and Bp50, is a receptor for TNFSF5/CD40LG. It is a member of the TNFR super family and is responsible for the efficient activation of cell-mediated and humoral immune responses via activated T cells and B cells respectively. Defects in CD40 lead to hyper-IgM immunodeficiency syndrome type 3 (HIGM3) . This is an autosomal recessive disorder that includes the inability of B cells to undergo isotype switching, a key step in the final differentiation of the humoral immune response, and an inability to mount an antibody-specific immune response.
Images
| Western blot analysis of BP50 (GB111033) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
