Your shopping cart is empty!
Anti-CD42b Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD42b rabbit polyclonal antibody |
Gene Name: | Platelet glycoprotein Ib alpha chain |
Synonyms: | GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, CD42b, BDPLT3, GLYCOCALICIN, VWDP, DBPLT3, CD42b-alpha |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD42b |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | O35930 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Rat | 1: 500-1: 1800 | lung, spleen |
Background
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Images
| Immunohistochemistry of paraffin embedded rat lung using GP1BA (GB112044) at dilution of 1:600 (300x lens) |
| Immunohistochemistry of paraffin embedded rat spleen using GP1BA (GB112044) at dilution of 1:500 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
