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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Macrosialin (Gp110) (CD antigen CD68) |
Gene ID: | 968 |
Immunogen: | Synthesized peptide derived from human CD68 |
Uniprot ID: | P34810 |
Source: | Mouse/IgG2b, kappa |
Concentration: | 1 mg/ml |
Purity: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Product Usage Information
IHC/IF | Human | 1: 200-1: 500 | gastric carcinoma, tonsil |
Background
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
Images
| Immunohistochemistry analysis of paraffin embedded human gastric carcinoma using CD68 (GB14043) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using CD68 (GB14043) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using CD68 (GB14043) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
