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Anti-CDKA1 / DOC1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CDKA1 / DOC1 rabbit polyclonal |
Gene Name: | Cyclin-dependent kinase 2-associated protein 1 |
Synonyms: | CDK2-associated protein 1, Deleted in oral cancer 1, DOC-1, Putative oral cancer suppressor, Cdk2ap1, Cdkap1, Doc1, p12DOC 1, ST19, DORC1 |
Immunogen: | Recombinant protein corresponding to Mouse CDKA1 / DOC1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 600-1: 1200 | colon, stomach, kidney |
Background
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Images
| Immunohistochemistry analysis of paraffin-embedded human colon using DOC1 (GB113222) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse colon using DOC1 (GB113222) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat colon using DOC1 (GB113222) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded human stomach using DOC1 (GB113222) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using DOC1 (GB113222) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
