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Anti-CDKN2A/p16INK4a Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CDKN2A/p16INK4a rabbit polyclonal antibody |
Gene Name: | Cyclin-dependent kinase inhibitor 2A |
Synonyms: | Cyclin-dependent kinase 4 inhibitor A, CDK4I, CDKN2A, MTS1, CDKN2 , Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16INK4A, p16-INK4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CDKN2A/p16INK4a |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 17 kDa |
Observed MW. | 17 kDa |
Uniprot ID: | P42771 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | HeLa, Saso-2, 293T, HepG2, HEK293 |
Background
This gene generates several transcript variants which differ in their first exons.There are at least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon and this transcript contains an alternate open reading frame (ARF) that ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Images
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Western blot analysis of p16 (GB111605) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
