Your shopping cart is empty!
| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Homeobox protein CDX-2 |
Synonyms: | caudal type homeobox 2, Caudal type homeobox protein 2, CDX-3, CDX2, CDX-2, CDX3 |
Immunogen: | Recombinant protein corresponding to Mouse CDX2 |
Uniprot ID: | P43241 |
Isotype: | IgG2b,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 1500-1: 3000 | colon cancer, colon |
Background
CDX2, also named as Homeobox protein CDX-2, is a 313 amino acid protein, which contains one homeobox DNA-binding domain and belongs to the Caudal homeobox family. CDX2 localizes in the nucleus and is involved in the transcriptional regulation of multiple genes expression in the intestinal epithelium. The relative expression of CDX1 to CDX2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis, and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.
Images
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using CDX2 (GB121500) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using CDX2 (GB121500) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded human colon using CDX2 (GB121500) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
