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Anti-CHD1L Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CHD1L rabbit polyclonal antibody |
Gene Name: | Chromodomain-helicase-DNA-binding protein 1-like |
Synonyms: | Chd1l, ALC1, Amplified in liver cancer 1, Amplified in liver cancer protein 1, EC 3.6.4.12, EC 3.6.1 |
Immunogen: | Recombinantproteincorresponding to Mouse CHD1L |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q9CXF7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 600-1: 2000 | testis |
Background
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes, and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage.DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair.
Images
| Immunohistochemistry of paraffin embedded mouse testis using CHD1L (GB111680) at dilution of 1:650 (300x lens) |
| Immunofluorescence of paraffin embedded mouse testis using CHD1L (GB111680) at dilution of 1:650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
