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Anti-CHMP1a Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CHMP1a rabbit polyclonal antibody |
Gene Name: | Charged multivesicular body protein 1a |
Synonyms: | Chromatin-modifying protein 1a, CHMP1a, Chmp1, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1 |
Immunogen: | Recombinant protein corresponding to Mouse CHMP1a |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 22 kDa |
Observed MW. | 27 kDa |
Uniprot ID: | Q9HD42, Q921W0 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, kidney, liver |
Background
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein PCGF4/BMI1 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
Images
| Western blot analysis of CHMP1A (GB111954) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
