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Anti-CIP2A Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CIP2A rabbit polyclonal antibody |
Gene Name: | Protein CIP2A |
Synonyms: | Cancerous inhibitor of PP2A, p90 autoantigen homolog, Cip2a, Kiaa1524, p90, FLJ12850 |
Immunogen: | Recombinant protein corresponding to Mouse CIP2A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 102 kDa |
Observed MW. | 102 kDa |
Uniprot ID: | Q8TCG1, Q8BWY9 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | testis |
Background
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Images
| Western blot analysis of CIP2A (GB111903) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
