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Anti-CPEB1 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cytoplasmic polyadenylation element-binding protein 1 |
Synonyms: | CEBP, CPE binding protein 1, CPE BP1, CPEB, CPEB1, h CEBP, hCPEB 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CPEB1 |
Uniprot ID: | P70166 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell junction |
Predicted MW. / Observed MW. | 62 kDa / 62 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | HeLa, SH-SY5Y, K562, Jurkat, Hep G2 |
IHC/IF | Human | 1: 800-1: 1600 | ovarian cancer, lung cancer, esophageal carcinoma |
Background
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses.
Images
| Western blot analysis of CPEB1 (GB114768) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human esophageal carcinoma using CPEB1 (GB114768) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human ovarian cancer using CPEB1 (GB114768) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using CPEB1 (GB114768) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
