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Anti-CTRP5 Rabbit pAb (100 μl)
| Reactivity: | M & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Complement C1q tumor necrosis factor-related protein 5 |
Synonyms: | CTRP5, DKFZp586B0621, LORD, C1QTNF5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CTRP5 |
Uniprot ID: | Q8K479 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. / Observed MW. | 25 kDa / 35-40 kDa |
Product Usage Information
WB | Mouse | 1: 1000-1: 2000 | brain |
IHC/IF | Rat | 1: 1200-1: 3600 | white fat |
Background
CTRP5 is a short-chain collagen that is expressed in retinal pigment epithelium as well as brain, lung, liver and placenta. By forming an extracellular hexagonal lattice, CTRP5 facilitates the adhesion of basal retinal pigment epithelium to Bruch’s membrane, the innermost layer of the choroid. A mutation within the C1q domain of CTRP5 results in abnormal high molecular weight aggregate formation, which alters its structure and interactions. This mutation may result in the presentation of late-onset retinal degeneration (LORD), an autosomal dominant disorder that is characterized by punctate yellow-white deposits in the retinal fundus and night blindness.
Images
| Western blot analysis of C1QTNF5 (GB114792) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded rat white fat using C1QTNF5 (GB114792) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
