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Anti-CUG-BP1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CUG-BP1 rabbit polyclonal antibody |
Gene Name: | CUGBP Elav-like family member 1 |
Synonyms: | CELF-1, 50 kDa nuclear polyadenylated RNA-binding protein, Brain protein F41, Bruno-like protein 2, CUG-BP1, CUG-BP- and ETR-3-like factor 1, EDEN-BP homolog, Brunol2, Cugbp, Cugbp1, Celf1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CUG-BP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | P28659, Q4QQT3 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:200-1:400 | brain, heart, spleen, testis |
Background
CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5’ region of p21 mRNA.
Images
Immunohistochemistry of paraffin embedded mouse brain using Celf1 (GB112305) at dilution of 1:200 (400x lens) | |
| Immunohistochemistry of paraffin embedded mouse heart using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
| Immunohistochemistry of paraffin embedded rat heart using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse heart using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
 | Immunofluorescence of paraffin embedded rat testis using Celf1 (GB112305) at dilution of 1:200 (300x lens) |
| Immunofluorescence of paraffin embedded rat brain using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
| Immunofluorescence of paraffin embedded rat spleen using Celf1 (GB112305) at dilution of 1:200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
