Your shopping cart is empty!
Anti-Calsequestrin 2 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Calsequestrin-2 |
Synonyms: | Calsequestrin 2, CASQ2, PDIB2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Calsequestrin 2 |
Uniprot ID: | O09161 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Sarcoplasmic reticulum |
Predicted MW. / Observed MW. | 48 kDa / 54 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | heart |
IHC/IF | Human, Mouse, Rat | 1: 1500-1: 4500 | skeletal muscle |
Background
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Images
| Western blot analysis of CASQ2 (GB114847) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded human skeletal muscle using CASQ2 (GB114847) at dilution of 1: 300 |
| Immunofluorescence of paraffin embedded rat skeletal muscle using CASQ2 (GB114847) at dilution of 1: 300 |
| Immunofluorescence of paraffin embedded mouse skeletal muscle using CASQ2 (GB114847) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
