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Anti-Caspase-3 Rabbit pAb (100 μl)
| Reactivity: | Human |
| Applications: | WB, IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | caspase 3 |
| Gene Symbol: | CASP3 |
| Synonyms: | CPP32; SCA-1; CPP32B |
| Immunogen: | Recombinant protein corresponding to Human Caspase-3 |
| Gene ID: | 836 |
| Uniprot ID: | P42574 |
| Isotype: | lgG |
| Purity: | Affinity purification |
| Subcellular location: | Cytoplasm |
| Documents: | Manual-CASP3 polyclonal antibody |
Product Usage Information
WB | Human | 1: 500-1: 1000 | Jurkat, THP-1, 293T |
IHC/IF | Human | 1: 700-1: 2100 | tonsil, colon, T-cell lymphoma |
Background
The protein encoded by the gene CASP3 is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Images
| Western blot analysis of Caspase-3 (GB115600) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon using Caspase-3 (GB115600) at dilution of 1:700 |
| Immunohistochemistry analysis of paraffin embedded human T-cell lymphoma using Caspase-3 (GB115600) at dilution of 1:700 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using Caspase-3 (GB115600) at dilution of 1:700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
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