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Anti-Caspase-9 Mouse mAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Caspase-9 |
Synonyms: | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase 9 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Caspase9 |
Uniprot ID: | Q8C3Q9 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 50 kDa / 35/46 kDa |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 100-1: 200 | skeletal muscle |
Background
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts (inactive form) with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin. Interacts with ABL1 (via SH3 domain); the interaction is direct and increased in the response of cells to genotoxic stress and ABL1/c-Abl activation.
Images
 | Western blot analysis of Caspase-9 (GB12053) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
