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Anti-Cdk4 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cdk4 rabbit polyclonal |
Gene Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CDK4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: | P11802, P30285, P35426 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Rat | 1: 100 | colon, breast, stomach, testis, ovary |
IF | Human, Rat | 1: 100 | colon, breast, stomach, testis, ovary |
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using CDK4 (GB11238-2) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded human breast using CDK4 (GB11238-2) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using CDK4 (GB11238-2) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded rat testis using CDK4 (GB11238-2) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded rat ovary using CDK4 (GB11238-2) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using CDK4 (GB11238-2) at dilution of 1: 100 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
