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| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Chk1 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHK1 checkpoint homolog, Checkpoint kinase-1, Chek1, Chk1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Chk1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q91ZN7 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 600-1: 1300 | lung, spleen, brain |
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks.
Images
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Immunohistochemistry of paraffin embedded rat brain using CHK1 (GB111146) at dilution of 1:650 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using CHK1 (GB111146) at dilution of 1:650 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using CHK1 (GB111146) at dilution of 1:650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
