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Anti-Claudin 18 Mouse mAb (50 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | CLDN18 UNQ778/PRO1572 |
| Protein Name: | Claudin-18 |
| Human Gene ID: | 51208 |
| Uniprot ID: | P56856 |
| Immunogen: | Synthesized peptide derived from human Claudin 18 |
| Specificity: | This antibody detects endogenous levels of human Claudin 18 |
| Source: | Mouse/IgG1, Lambda |
| Concentration: | 1 mg/ml |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Product Usage Information
| Applications | Species | Dilution | |
| IHC、IF | Human | 1:200-1:500 |
Background
claudin 18(CLDN18) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],
Images
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Immunohistochemical analysis of paraffin-embedded Stomach. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. |
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Immunohistochemical analysis of paraffin-embedded Stomach. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
