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Anti-Coiled-coil domain-containing protein 111 Rabbit pAb (100 μl)
| Reactivity: | M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Coiled-coil domain-containing protein 111 rabbit polyclonal antibody |
Gene Name: | DNA-directed primase/polymerase protein |
Synonyms: | Primpol, CCDC111, MYP22 |
Immunogen: | Recombinant protein corresponding to Mouse CCDC111 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion, Nucleus |
Predicted MW. | 61 kDa |
Observed MW. | 64 kDa |
Uniprot ID: | Q6P1E7, Q96LW4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | liver |
IHC/IF | Human | 1: 700-1: 1400 | placenta |
Background
DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them . Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA .
Images
| Western blot analysis of CCDC111 (GB112314) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded human placenta using CCDC111 (GB112314) at dilution of 1:700 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
