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Anti-Constitutive androstane receptor Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nr1i3 rabbit polyclonal antibody |
Gene Name: | Nuclear receptor subfamily 1 group I member 3 |
Synonyms: | Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, Nr1i3, Car, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3 |
Immunogen: | Recombinant protein corresponding to Mouse Nr1i3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 41 kDa |
Observed MW. | 41 kDa |
Uniprot ID: | O35627, Q9QUS1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | liver |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | hepatitis |
Background
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription.
Images
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Western blot analysis of NR1I3 (GB111418) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded mouse hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens) |
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Immunohistochemistry of paraffin embedded rat hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
