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Anti-Coxsackie Adenovirus Receptor/hCAR Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Coxsackie Adenovirus Receptor/hCAR rabbit polyclonal |
Gene Name: | Coxsackievirus and adenovirus receptor homolog |
Synonyms: | CAR, CVB3 binding protein, CXADR, HCAR, HCVADR, mCAR, Coxsackie virus B receptor, 46 kD coxsackievirus and adenovirus receptor protein, CAR4/6 |
Immunogen: | Recombinant protein corresponding to Mouse Coxsackie Adenovirus Receptor/hCAR |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 40 kDa |
Observed MW. | 50 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 1000-1: 2000 | Caco-2, HepG2, HaCat, NIH/3T3 |
Background
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Images
 | Western blot analysis of CXADR (GB113658) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
