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Anti-Cyclin E1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cyclin E1 rabbit polyclonal antibody |
Gene Name: | G1/S-specific cyclin-E1 |
Synonyms: | CCNE1, CCNE, pcyclin E1, Cyclin E1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Cyclin E1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P24864, Q61457 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 250-1: 1000 | colon, placenta, testis |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
Images
| Immunohistochemistry of paraffin embedded human placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse testis using cyclinE1 (GB111937) at dilution of 1:500 (300x lens) |
| Immunohistochemistry of paraffin embedded mouse colon using cyclinE1 (GB111937) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat testis using cyclinE1 (GB111937) at dilution of 1:500 (300x lens) |
| Immunohistochemistry of paraffin embedded rat placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
