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Anti-Cyclin E1 Rabbit pAb (50 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cyclin E1 rabbit polyclonal |
Gene Name: | G1/S-specific cyclin-E1 |
Synonyms: | CCNE1, CCNE, pcyclin E1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to rat Cyclin E1. |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 47 kDa |
Observed MW. | 47 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 3000 | brain, testis, liver |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
Images
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Western blot analysis of Cyclin E1 (GB13305) at dilution of 1:3000. Lane 1: HeLa cell lysate Lane 2: A549 cell lysate Lane 3: HepG2 cell lysate Lane 4: Mouse brain tissue lysate Lane 5: Mouse testis tissue lysate Lane 6: Mouse liver tissue lysate Lane 7: Rat brain tissue lysate Lane 8: Rat testis tissue lysate Lane 9: Rat liver tissue lysate
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Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
