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Anti-Cytokeratin 1 Mouse mAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Keratin, type II cytoskeletal 1 |
Synonyms: | 67 kDa cytokeratin, Cytokeratin-1, Keratin-1, CK-1, K1, Type-II keratin Kb1, Krt1, Krt2-1, EHK1, Keratin type II cytoskeletal 1 |
Immunogen: | KLH conjugated Synthetic peptidecorresponding to Human Cytokeratin 1 |
Uniprot ID: | P04264 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 66 kDa / 66 kDa |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | A-431 |
Background
Cytokeratin 1 is a heterotetramer of two type I as well as two type II keratins localized in the cell membrane and is generally associated with keratin-10 . It has been suggested to regulate the activity of kinases such as PKC/SRC via binding to integrin beta-1 and the receptor of activated protein kinase C. Cytokeratin 1 and its heterodimer partner KRT10 are the major constituents of 4 intermediate filament cytoskeleton in suprabasal epidermis/keratinocytes, and their upregulation precedes expression of filaggrin and cornified envelope proteins.
Images
 | Western blot analysis of CK1 (GB121017) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
