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Anti-Cytokeratin 17 Mouse mAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Keratin, type I cytoskeletal 17 |
Synonyms: | Cytokeratin-17, CK-17, Keratin-17, Krt1-17, Krt17, K17, keratin 17 epitope S1, PCHC1, PC2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Cytokeratin 17 |
Uniprot ID: | |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. / Observed MW. | 48 kDa / 48 kDa |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 2000 | HeLa, A431, Siha, Hacat |
IHC/IF | Human | 1: 500-1: 1000 | cervical cancer, esophageal cancer, laryngeal cancer |
Background
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.
Images
| Western blot analysis of CK17 (GB12363) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded human cervical cancer using CK17 (GB12363) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using CK17 (GB12363) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human laryngeal cancer using CK17 (GB12363) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
