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Anti-DDIT3/CHOP Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DDIT3 rabbit polyclonal |
Gene Name: | DNA damage-inducible transcript 3 protein |
Synonyms: | DDIT3, CEBPZ, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3, DNA damage inducible transcript 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CHOP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1:500-1:1000 | stomach cancer, brain |
IF | Human, Mouse, Rat | 1:500-1:1000 | stomach cancer, brain |
Background
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Images
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using DDIT3/CHOP (GB11204) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using DDIT3/CHOP (GB11204) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using DDIT3/CHOP (GB11204) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded mouse striatum using DDIT3/CHOP (GB11204) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded rat striatum using DDIT3/CHOP (GB11204) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
