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| Reactivity: | H,M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DEF6 rabbit polyclonal antibody |
Gene Name: | Differentially expressed in FDCP 6 |
Synonyms: | DEF-6, DEF6, IBP, IRF4 binding protein, SLAT, SWAP-70-like adapter of T-cells |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DEF6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Nucleus, Cytoplasm, Cytoskeleton |
Predicted MW. | 73 kDa |
Observed MW. | 73 kDa |
Uniprot ID: | Q8C2K1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | spleen, thymus, lymph node |
IHC/IF | Mouse | 1: 800-1: 1600 | spleen |
Background
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity (By similarity).
Images
 | Western blot analysis of DEF6 (GB114053) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse spleen using DEF6 (GB114053) at dilution of 1: 1600 |
| Immunofluorescence analysis of paraffin embedded mouse spleen using DEF6 (GB114053) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
