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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Tumor necrosis factor receptor superfamily member 10A |
Synonyms: | APO2, CD261, Death receptor 4, DR4, TNFRSF10A, TRAIL R1, TRAIL receptor 1, TRAILR 1, TRAILR1 |
Immunogen: | Recombinant protein corresponding to Human TNFRSF10A |
Uniprot ID: | O00220 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 50 kDa / 45-60 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | K562, Jurkat , THP-1 |
Background
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Images
| Western blot analysis of DR4 (GB114382) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
