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| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Daxx rabbit polyclonal antibody |
Gene Name: | Death domain-associated protein 6 |
Synonyms: | Daxx, BING2, DAP6, EAP1, Death-domain associated protein, Death domain associated protein |
Immunogen: | Recombinant protein corresponding to Mouse Daxx |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 82 kDa |
Observed MW. | 110 kDa |
Uniprot ID: | Q9UER7, O35613, Q8VIB2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 1000-1: 1500 | brain, cerebral cortex |
IHC/IF | Mouse, Rat | 1: 750-1: 3000 | brain, kidney, pancreas, spleen, testis |
Background
Daxx, a Death domain-associated protein, is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. Daxx serves as an H3.3 specific histone chaperone, interacting with an H3.3/H4 dimer. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. In the cytoplasm, the encoded protein may function to regulate apoptosis.
Images
 | Western blot analysis of Daxx (GB11754) at dilution of 1: 1000 |
 | Immunohistochemistry of paraffin embedded mouse brain using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse kidney using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spleen using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat pancreas using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using Daxx (GB11754) at dilution of 1: 1500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
