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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Desmin |
Synonyms: | DES, CSM1, CSM2, LGMD2R, desmin |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Desmin |
Uniprot ID: | P17661 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 200-1: 2000 | esophagus, colon cancer, heart |
Background
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures . May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction.
Images
| Immunohistochemistry analysis of paraffin embedded human esophagus using desmin (GB12074) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using desmin (GB12074) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using desmin (GB12074) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat heart using desmin (GB12074) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat colon using desmin (GB12074) at dilution of 1: 2000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
