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Anti-Desmuslin/SYN Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Desmuslin/SYN rabbit polyclonal antibody |
Gene Name: | Synemin |
Synonyms: | Desmuslin, DMN, KIAA0353, SYN, Synemin, SYNM |
Immunogen: | Recombinant protein corresponding to Mouse Desmuslin/SYN |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q70IV5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1300 | bladder, colon, heart, testis |
Background
SYNM, also named as DMN, KIAA0353 and SYN, belongs to the intermediate filament family. SYNM is a Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Images
| Immunohistochemistry of paraffin embedded mouse colon using Desmuslin (GB111853) at dilution of 1:500 (200x lens) |
| Immunohistochemistry of paraffin embedded mouse heart using Desmuslin (GB111853) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse testis using Desmuslin (GB111853) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat testis using Desmuslin (GB111853) at dilution of 1:500 (250x lens) |
| Immunohistochemistry of paraffin embedded rat bladder using Desmuslin (GB111853) at dilution of 1:500 (300x lens) |
| Immunofluorescence of paraffin embedded mouse bladder using Desmuslin (GB111853) at dilution of 1:650 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse heart using Desmuslin (GB111853) at dilution of 1:650 (300x lens) |
 | Immunofluorescence of paraffin embedded rat bladder using Desmuslin (GB111853) at dilution of 1:650 (300x lens) |
| Immunofluorescence of paraffin embedded rat colon using Desmuslin (GB111853) at dilution of 1:650 (300x lens) |
| Immunofluorescence of paraffin embedded rat testis using Desmuslin (GB111853) at dilution of 1:650 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
