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Anti-Dnmt3a Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Dnmt3a rabbit polyclonal antibody |
Gene Name: | DNA (cytosine-5)-methyltransferase 3A |
Synonyms: | Dnmt3a, DNA methyltransferase MmuIIIA, DNA MTase MmuIIIA, M.MmuIIIA, Dnmt3a |
Immunogen: | Recombinant protein corresponding to Mouse Dnmt3a |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | O88508, Q1LZ53 |
Applications
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 3200 | colon, embryonic mouse, embryonic rat, kidney, lymph node, placenta, spleen, testis |
Background
Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process.
Images
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Immunohistochemistry of paraffin embedded mouse embryonic mouse using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse placenta using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat colon using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat placenta using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens) |
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Immunofluorescence of paraffin embedded mouse kidney using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens) |
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Immunofluorescence of paraffin embedded mouse placenta using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens) |
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Immunofluorescence of paraffin embedded mouse testis using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens) |
| Immunofluorescence of paraffin embedded rat embryonic rat using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens) |
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Immunofluorescence of paraffin embedded rat lymph node using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
