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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Microtubule-associated protein RP/EB family member 3 |
Synonyms: | End binding protein 3, MAPRE3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse EB3 |
Uniprot ID: | Q6PER3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 32 kDa / 36 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 2000-1: 3000 | brain |
Background
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. May play a role in cell migration.
Images
| Western blot analysis of MAPRE3 (GB115026) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
