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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | EMP2 rabbit polyclonal antibody |
Gene Name: | Epithelial membrane protein 2 |
Synonyms: | EMP-2, Epithelial membrane protein 2, Protein XMP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse EMP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Nucleus |
Uniprot ID: | O88662 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 100-1: 200 | lung, skin |
Background
This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10).
Images
| Immunohistochemistry of paraffin embedded human lung using EMP2 (GB113929) at dilution of 1: 100 (400x lens) |
| Immunohistochemistry of paraffin embedded human skin using EMP2 (GB113929) at dilution of 1: 100 (400x lens) |
| Immunofluorescence of paraffin embedded embedded human lung using EMP2 (GB113929) at dilution of 1: 100 (200x lens) |
| Immunofluorescence of paraffin embedded embedded human skin using EMP2 (GB113929) at dilution of 1: 100 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
