Reactivity: | M,R |
Applications: | WB |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Full Name: | FAK rabbit polyclonal antibody |
Gene Name: | Focal adhesion kinase 1 |
Synonyms: | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2 |
Immunogen: | Recombinant protein corresponding to Mouse FAK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Plasma membrane, Cytoskeleton |
Uniprot ID: | Q05397, P34152, O35346 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:1000-1:2000 | brain, breast cancer, heart, kidney |
Background
FAK is a protein of 125 kD recruited as a participant in focal adhesion dynamics between cells, and has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src. This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival.
Images
Immunohistochemistry of paraffin embedded human breast cancer using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human kidney using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat heart using FAK (GB11545) at dilution of 1:1000 (400x lens) |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |