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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FE65 rabbit polyclonal antibody |
Gene Name: | Amyloid-beta A4 precursor protein-binding family B member 1 |
Synonyms: | Protein Fe65, Apbb1, Fe65, Fe65 protein, RIR, Stat like protein, Amyloid beta A4 precursor protein binding family B |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FE65 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Nucleus |
Uniprot ID: | Q9QXJ1, P46933 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 100-1: 600 | brain, kidney |
Background
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription.
Images
Immunohistochemistry of paraffin embedded human kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) | |
| Immunohistochemistry of paraffin embedded mouse brain using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunofluorescence of paraffin embedded human kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunofluorescence of paraffin embedded rat brain using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
| Immunofluorescence of paraffin embedded rat kidney using APBB1 (GB112297) at dilution of 1:100 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
