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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Flavin-containing monooxygenase 5 |
Synonyms: | Dimethylaniline oxidase 5, FMO-5, FMO5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FMO5 |
Uniprot ID: | P97872 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 60 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse | 1: 800-1: 1500 | liver |
Background
Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects .
Images
| Western blot analysis of FMO5 (GB114812) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
