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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Zinc finger protein ZFPM2 |
Synonyms: | Friend of GATA protein 2, FOG-2, Friend of GATA 2, mFOG-2, Zinc finger protein multitype 2, Zfpm2, Fog2 |
Immunogen: | Recombinant protein corresponding to Mouse FOG2 |
Uniprot ID: | Q8CCH7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 128 kDa / 128 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | heart |
IHC/IF | Mouse, Rat | 1: 300-1: 3000 | cerebellum, heart |
Background
FOG-2 is the transcriptional cofactors of FOG family . FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.
Images
| Western blot analysis of Zfpm2 (GB112707) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse cerebellum using Zfpm2 (GB112707) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using Zfpm2 (GB112707) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded rat cerebellum using Zfpm2 (GB112707) at dilution of 1: 900 |
| Immunofluorescent analysis of paraffin embedded mouse hippocampus using ZFPM2 (GB112707) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
