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Anti-FOXK1/MNF Rabbit pAb (100 μl)
| Reactivity: | H & H,M,R & H,M,R |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FOXK1/MNF rabbit polyclonal |
Gene Name: | Forkhead box protein K1 |
Synonyms: | Myocyte nuclear factor, MNF, Foxk1, Fork head, FHX |
Immunogen: | Recombinant protein corresponding to Mouse FOXK1/MNF |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 75 kDa |
Observed MW. | 97 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | HeLa, 293T, H1299 |
| IHC | Human, Mouse, Rat | 1: 1000-1: 2000 | |
| IF | Human, Mouse, Rat | 1: 650-1: 1300 |
Background
The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. In skeletal muscles, undifferentiated myogenic stem cells (satellite cells) can mobilize to regenerate myofibers in response to injury. FOXK1 is expressed in these cells and regulates cell cycle progression through an interaction with its downstream target the cyclin-dependent kinase inhibitor p21 (CIP). Loss of FOXK1 in mice results in growth retardation and a severe impairment in skeletal muscle regeneration following injury. FOXK1 also shows expression in immature tissues of brain, eye, heart, lung and thymus.
Images
 | Western blot analysis of FOXK1 (GB112183) at dilution of 1: 1000 Lane 1: HeLa cell lysate Lane 2: 293T cell lysate Lane 3: H1299 cell lysate |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
