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Anti-FOXO4/AFX Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FOXO4 rabbit polyclonal antibody |
Gene Name: | Forkhead box protein O4 |
Synonyms: | Fork head domain transcription factor AFX1, FOXO4, AFX, AFX1, MLLT7 |
Immunogen: | Recombinant protein corresponding to Human FOXO4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 54 kDa |
Observed MW. | 54 kDa |
Uniprot ID: | P98177, D4A433 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Rat | 1: 500-1: 1000 | 293T, MDA-MB-231, Jurkat |
Background
FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias.
Images
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Western blot analysis of FOXO4 (GB111173) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
