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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FRK rabbit polyclonal antibody |
Gene Name: | Tyrosine-protein kinase FRK |
Synonyms: | Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, FRK, Bsk, Iyk |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FRK |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 59 kDa |
Observed MW. | 57 kDa |
Uniprot ID: | P42685, Q922K9 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | kidney, colon |
Background
The FRK is a non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Images
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Western blot analysis of FRK (GB111299) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
