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| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Tumor necrosis factor receptor superfamily member 6 |
Synonyms: | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Fas |
Uniprot ID: | P25446 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Secreted |
Product Usage Information
IHC/IF | Human, Mouse | 1: 200-1: 800 | gallbadder, colon |
Background
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Images
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Immunohistochemistry analysis of paraffin-embedded human gallbladder using FAS (GB12089) at dilution of 1:200 |
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Immunohistochemistry analysis of paraffin-embedded mouse colon using FAS (GB12089) at dilution of 1:400 |
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Immunohistochemistry analysis of paraffin-embedded mouse testis using FAS (GB12089) at dilution of 1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
