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Anti-Fibrinogen gamma chain Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Fibrinogen gamma chain |
Synonyms: | FGG, fibrinogen gamma chain |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FGG |
Uniprot ID: | Q8VCM7 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. / Observed MW. | 49 kDa / 50 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 600 | liver, pancreas |
Background
Together with fibrinogen alpha and fibrinogen beta , polymerizes to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Images
| Western blot analysis of Fibrinogen gamma chain (GB115571) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
