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Anti-Filamin A Rabbit pAb (100 μl)
| Reactivity: | H,M & M,R & M |
| Applications: | WB & IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Filamin-A |
Synonyms: | Flna, FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, Filamin A, FGS2 |
Immunogen: | Recombinant protein corresponding to Mouse Filamin A |
Uniprot ID: | Q8BTM8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 282 kDa / 282 kDa |
Images
WB | Human, Mouse | 1: 500-1: 1000 | liver |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | heart, liver, myocardial infarction |
ICC/IF | Mouse | 1: 100-1: 400 | NIH-3T3 |
Background
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Images
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Western blot analysis of FLN-A (GB11884) at dilution of 1: 500 |
 | Immunohistochemistry of paraffin embedded mouse heart using FLN-A (GB11884) at dilution of 1: 1000 (250x lens) |
 | Immunohistochemistry of paraffin embedded mouse liver using FLN-A (GB11884) at dilution of 1: 1000 (250x lens) |
 | Immunohistochemistry of paraffin embedded rat heart using FLN-A (GB11884) at dilution of 1: 1000 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse heart using FLN-A (GB11884) at dilution of 1: 1000 (200x lens) |
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Immunofluorescence of paraffin embedded mouse myocardial infarction using FLN-A (GB11884) at dilution of 1: 1000 (200x lens) |
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Immunofluorescence of paraffin embedded mouse prefrontal lobe using FLN-A (GB11884) at dilution of 1: 1000 (250x lens) |
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Immunofluorescence of paraffin embedded mouse skeletal muscle using FLN-A (GB11884) at dilution of 1: 1000 (250x lens) |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using Filamin A(GB11884) at dilution of 1:100-1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
